Selective cancer cell cytotoxicity from exposure to dihydroartemisinin and holotransferrin
Identifieur interne : 002A82 ( Main/Exploration ); précédent : 002A81; suivant : 002A83Selective cancer cell cytotoxicity from exposure to dihydroartemisinin and holotransferrin
Auteurs : Henry Lai [États-Unis] ; Narendra P. Singh [États-Unis]Source :
- Cancer Letters [ 0304-3835 ] ; 1995.
English descriptors
- Teeft :
- Antimalarial, Antimalarial action, Antimalarial activity, Artemisinin, Cancer cells, Cell counts, Cell viability, Clin, Control samples, Dihydroartemisinin, Drug combination, Free iron, Holotransferrin, Human lymphocytes, Lymphocyte, Malarial, Median test, Microfuge, Normal cells, Normal lymphocytes, Parasite, Percent cell counts, Plasmodium, Probit analysis, Qinghaosu, Receptor, Significant difference, Transferrin, Transferrin receptors.
Abstract
Abstract: Rapid cell death, as evidenced by a decrease in cell counts, was observed when molt-4-lymphoblastoid cells, a human leukemia cell line, were exposed to holotransferrin (12 μM) and dihydroartemisinin (1–200 μM). Incubation with either compound alone was significantly less effective. Significantly less cell death was observed when normal human lymphocytes were exposed to a combination of these 2 drugs. Probit analysis of dose-response functions shows that the drug combination is approximately 100 times more effective on molt-4 cells than lymphocytes (LD50s for molt-4 and lymphocytes were 2.59 μM and 230 μM, respectively). This drug combination may provide a novel approach for cancer treatment.
Url:
DOI: 10.1016/0304-3835(94)03716-V
Affiliations:
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Le document en format XML
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Singh</name><affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychiatry & Behavioral Sciences, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author></analytic><monogr></monogr><series><title level="j">Cancer Letters</title><title level="j" type="abbrev">CAN</title><idno type="ISSN">0304-3835</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1995">1995</date><biblScope unit="volume">91</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="41">41</biblScope><biblScope unit="page" to="46">46</biblScope></imprint><idno type="ISSN">0304-3835</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0304-3835</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Antimalarial</term><term>Antimalarial action</term><term>Antimalarial activity</term><term>Artemisinin</term><term>Cancer cells</term><term>Cell counts</term><term>Cell viability</term><term>Clin</term><term>Control samples</term><term>Dihydroartemisinin</term><term>Drug combination</term><term>Free iron</term><term>Holotransferrin</term><term>Human lymphocytes</term><term>Lymphocyte</term><term>Malarial</term><term>Median test</term><term>Microfuge</term><term>Normal cells</term><term>Normal lymphocytes</term><term>Parasite</term><term>Percent cell counts</term><term>Plasmodium</term><term>Probit analysis</term><term>Qinghaosu</term><term>Receptor</term><term>Significant difference</term><term>Transferrin</term><term>Transferrin receptors</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Rapid cell death, as evidenced by a decrease in cell counts, was observed when molt-4-lymphoblastoid cells, a human leukemia cell line, were exposed to holotransferrin (12 μM) and dihydroartemisinin (1–200 μM). Incubation with either compound alone was significantly less effective. Significantly less cell death was observed when normal human lymphocytes were exposed to a combination of these 2 drugs. Probit analysis of dose-response functions shows that the drug combination is approximately 100 times more effective on molt-4 cells than lymphocytes (LD50s for molt-4 and lymphocytes were 2.59 μM and 230 μM, respectively). This drug combination may provide a novel approach for cancer treatment.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Washington (État)</li></region><settlement><li>Seattle</li></settlement><orgName><li>Université de Washington</li></orgName></list><tree><country name="États-Unis"><region name="Washington (État)"><name sortKey="Lai, Henry" sort="Lai, Henry" uniqKey="Lai H" first="Henry" last="Lai">Henry Lai</name></region><name sortKey="Singh, Narendra P" sort="Singh, Narendra P" uniqKey="Singh N" first="Narendra P." last="Singh">Narendra P. Singh</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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